Behavior of Betamethasone-17-valerate in Acidic or Alkaline Medium

Betamethasone 17-valerate by aerosol in childhood asthma

Frears, J. F., Wilson, L. C., and Friedman, M. (1973). Archives of Disease in Childhood, 48, 856. Betamethasone 17-valerate by aerosol in childhood asthma. A double-blind cross-over trial of betamethasone 17-valerate (B17V) administered by aerosol was carried out by alternating two placebo periods with two treated periods at monthly intervals in 20 children with severe asthma. During the trial,...

Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability.

BACKGROUND The bioavailability of most topically delivered drugs is difficult to quantify, but is generally believed to be very low. With the exception of the vasoconstrictor assay for corticosteroids, no methodology to quantify the rate and extent of drug delivery to the skin has been validated. Recent research has examined the dermatopharmacokinetic (DPK) technique, which is based on stratum ...

Proceedings: Experience with betamethasone 17-valerate by aerosol in childhood asthma.

Frears, J. F., Wilson, L. C., and Friedman, M. (1973). Archives of Disease in Childhood, 48, 856. Betamethasone 17-valerate by aerosol in childhood asthma. A double-blind cross-over trial of betamethasone 17-valerate (B17V) administered by aerosol was carried out by alternating two placebo periods with two treated periods at monthly intervals in 20 children with severe asthma. During the trial,...

Comparison of betamethasone 17-valerate ointment with fluocortolone and fluocortolone caproate ointment.

Topical corticosteroids have revolutionized the therapy of many dermatoses. The value to the dermatologist of commercially available preparations reflects many factors, including the cost, potency, therapeutic efficiency, and cosmetic acceptability of the medicaments. Furthermore, since the pharmacology of most corticosteroids is similar, and the newer fluorinated compounds are of high potency,...

Betamethasone 17-valerate: a new alcoholic formulation for psoriasis of the scalp.